A dynamic activation model for T cell signaling

p/MHC-induced allosteric changes in the constant regions of the T cell receptor may trigger a signaling cascade by promoting CD3 interactions

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Atomic model of an intact Virus capsid

The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope

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Atomic structure of the Type-III secretion system needle

The structure of the T3SS needle from Salmonella typhimurium provides new insights into a conserved bacterial seretion pathway

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Structural Model of a parallel Amyloid fibril

Modeling the structure of a distinct structural polymorph implicated in the Iowa variant of familial Alzheimer's Disease

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Solution structure of a Viral Immunoevasin protein

The NMR/Rosetta structure of m04 from mouse Cytomegalovirus reveals a novel Immunoevasin fold with diverse functions

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Welcome to the Sgourakis Research group at UC Santa Cruz !

We study proteins of the immune system that play important roles in human health, infectious disease, and cancer. To perform their role, these proteins must interact with biomolecules, such as other proteins and/or peptides. Elucidating these molecular interactions at high resolution will provide information towards understanding the biochemistry of pathogenesis. To achieve our goals, we employ a variety of state-of-the-art biophysical techniques, including X-ray crystallography, fluorescence spectroscopy, solution NMR, and computational modeling.

Determining the molecular basis of protein-protein interactions and their dynamics would help understand fundamental biological mechanisms towards the design of novel therapeutics.

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