Welcome to the Sgourakis Research group at UC Santa Cruz !
We study proteins of the immune system that play important roles in human health, infectious disease, and cancer. To perform their role, these proteins must interact with biomolecules, such as other proteins and/or peptides. Elucidating these molecular interactions at high resolution will provide information towards understanding the biochemistry of pathogenesis. To achieve our goals, we employ a variety of state-of-the-art biophysical techniques, including X-ray crystallography, fluorescence spectroscopy, solution NMR, and computational modeling.
Determining the molecular basis of protein-protein interactions and their dynamics would help understand fundamental biological mechanisms towards the design of novel therapeutics.