A dynamic activation model for T cell signaling


p/MHC-induced allosteric changes in the constant regions of the T cell receptor may trigger a signaling cascade by promoting CD3 interactions

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Atomic model of an intact Virus capsid


The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope

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Atomic structure of the Type-III secretion system needle


The structure of the T3SS needle from Salmonella typhimurium provides new insights into a conserved bacterial seretion pathway

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Structural Model of a parallel Amyloid fibril


Modeling the structure of a distinct structural polymorph implicated in the Iowa variant of familial Alzheimer's Disease

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Solution structure of a Viral Immunoevasin protein


The NMR/Rosetta structure of m04 from mouse Cytomegalovirus reveals a novel Immunoevasin fold with diverse functions

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Welcome to the Sgourakis Research group at UC Santa Cruz !

We study proteins of the immune system that play important roles in human health. To perform their role, these proteins must interact with other biomolecules, such as other protein receptors and smaller peptides. Elucidating these molecular interactions at high resolution will help establish the biochemical basis of immune recognition. Besides obtaining an unprecedented basic science understanding of fundamental biological processes, the knowledge gained from our detailed molecular description will enable us to develop new therapeutic molecules for emerging immunotherapy applications to combat viral infections, autoimmune diseases and cancer.

To achieve these goals, we employ a variety of state-of-the-art biophysical techniques, including X-ray crystallography, fluorescence spectroscopy, solution NMR, and computational modeling, followed upon  by experiments using cell lines.

View Research Papers on PubMed

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