We study the chemical basis of immune recognition processes and their role in health & disease.
Dynamically-driven protein interaction networks are essential for the emergence of adaptive immune function. Elucidating molecular interactions between antigens and their receptors provides the biochemical basis of immune responses, and autoimmunity.
We develop and apply integrative structural biology methods, bridging data sets from solution NMR, X-ray crystallography, cryoelectron microscopy and computational modeling. Our mechanistic/structural findings are complemented using experiments in cell lines and animal models.
Besides obtaining an unprecedented understanding of fundamental biological processes, the knowledge gained from our detailed characterization allows us to develop protein-based reagents for emerging diagnostic and therapeutic applications in viral infections, autoimmune diseases, and cancer.