A dynamic activation model for T cell signaling

Using solution NMR, we have elucidated conformational changes in the T cell receptor upon recognition of the MHC antigen. The allosteric sites are adjacent to the CD3 co-receptor binding site, and are important for efficient T cell signaling.

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Atomic model of an intact Virus capsid


The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope

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Atomic structure of the Type-III secretion system needle


The structure of the T3SS needle from Salmonella typhimurium provides new insights into a conserved bacterial seretion pathway

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Structural Model of a parallel Amyloid fibril


Modeling the structure of a distinct structural polymorph implicated in the Iowa variant of familial Alzheimer's Disease

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Solution structure of a Viral Immunoevasin protein


The NMR/Rosetta structure of m04 from mouse Cytomegalovirus reveals a novel Immunoevasin fold with diverse functions

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Welcome to the Sgourakis Research Group at UC Santa Cruz !

Read UCSC Press release on recent work from our Lab

We study the chemical basis of immune recognition processes and their role in health & disease.

Dynamically-driven protein interaction networks are essential for the emergence of adaptive immune function. Elucidating molecular interactions between antigens and their receptors provides the biochemical basis of immune responses, and autoimmunity.

We develop and apply integrative structural biology methods, bridging data sets from solution NMR, X-ray crystallography, cryoelectron microscopy and computational modeling. Our mechanistic/structural findings are complemented using experiments in cell lines and animal models.

Besides obtaining an unprecedented understanding of fundamental biological processes, the knowledge gained from our detailed characterization allows us to develop protein-based reagents for emerging diagnostic and therapeutic applications in viral infections, autoimmune diseases, and cancer.

View research papers on PubMed